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What is tramadol? Tramadol is a narcotic-like pain reliever. Tramadol is used to treat moderate to severe pain. The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain. Tramadol may also be used for purposes not listed in this medication guide. Important information You should not take tramadol if you have used alcohol, sedatives, tranquilizers, or narcotic medications within the past few hours. Tramadol can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never take tramadol in larger amounts, or for longer than prescribed. Do not crush, break, or open an extended-release pill. Swallow it whole to avoid exposure to a potentially fatal dose. Slideshow: Breaking Down Bipolar Disorder - 12 Things You Need To Know Breaking Down Bipolar Disorder - 12 Things You Need To Know Seizures (convulsions) have occurred in some people taking this medicine. Tramadol may be more likely to cause a seizure if you have a history of seizures or head injury, a metabolic disorder, or if you are taking certain medicines such as antidepressants, muscle relaxers, narcotic, or medicine for nausea and vomiting Tramadol may be habit-forming, even at regular doses. Take this medicine exactly as prescribed by your doctor. Never share the medicine with another person. MISUSE OF NARCOTIC PAIN MEDICATION CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Tell your doctor if you are pregnant. Tramadol may cause life-threatening addiction and withdrawal symptoms in a newborn. Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with tramadol. Do not crush the tramadol tablet. This medicine is for oral (by mouth) use only. Powder from a crushed tablet should not be inhaled or diluted with liquid and injected into the body. Using this medicine by inhalation or injection can cause life-threatening side effects, overdose, or death. Before taking this medicine You should not take tramadol if you are allergic to it, or if you have: severe asthma or breathing problems; a blockage in your stomach or intestines; if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications. Seizures have occurred in some people taking tramadol. Talk with your doctor about your seizure risk, which may be higher if you have: a history of head injury, epilepsy or other seizure disorder; a history of drug or alcohol addiction; a metabolic disorder; or if you are also using certain medicines to treat migraine headaches, muscle spasms, depression, mental illness, or nausea and vomiting. To make sure tramadol is safe for you, tell your doctor if you have: liver or kidney disease; a stomach disorder; or a history of drug abuse, alcohol addiction, mental illness, or suicide attempt. Tramadol is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated. Tramadol may be habit forming and should be used only by the person it was prescribed for. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away tramadol to any other person is against the law. FDA pregnancy category C. It is not known whether this medicine will harm an unborn baby. Tramadol may cause breathing problems, behavior changes, or life-threatening addiction and withdrawal symptoms in your newborn if you use the medication during pregnancy. Tell your doctor if you are pregnant. See also: Pregnancy and breastfeeding warnings (in more detail) Tramadol can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking this medicine. Do not give this medication to anyone younger than 16 years old without the advice of a doctor. Ultram ER should not be given to anyone younger than 18 years old. Rybix ODT may contain phenylalanine. Talk to your doctor before using this form of tramadol if you have phenylketonuria (PKU). How should I take tramadol? Take tramadol exactly as prescribed. Follow all directions on your prescription label. Tramadol can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never take in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain. Stop taking all other around-the-clock narcotic pain medications when you start taking tramadol. Tramadol can be taken with or without food, but take it the same way each time. Do not crush, break, or open an extended-release tablet or capsule (ConZip, Ryzolt, Ultram ER). Swallow it whole to avoid exposure to a potentially fatal dose. Never crush or break a tramadol pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death with the misuse of tramadol and similar prescription drugs. To take tramadol orally disintegrating tablets (Rybix ODT): Keep the tablet in its blister pack until you are ready to take it. Use dry hands to remove the tablet and place it in your mouth. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet. If you use the tramadol extended-release tablet, the tablet shell may pass into your stools (bowel movements). This is normal and does not mean that you are not receiving enough of the medicine. Do not stop using tramadol suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine. Store at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Tramadol is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. What happens if I miss a dose? Since tramadol is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A tramadol overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, cold and clammy skin, and fainting. What should I avoid? Do not drink alcohol. Dangerous side effects or death can occur when alcohol is combined with tramadol. Check your food and medicine labels to be sure these products do not contain alcohol. Tramadol may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents. Tramadol side effects Get emergency medical help if you have any of these signs of an allergic reaction to tramadol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: seizure (convulsions); weak or shallow breathing; high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; or severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. Common tramadol side effects may include: headache, dizziness, drowsiness, tired feeling; constipation, diarrhea, nausea, vomiting, stomach pain; or feeling nervous or anxious. itching, sweating, flushing (warmth, redness, or tingly feeling). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. See also: Side effects (in more detail) Tramadol dosing information Usual Adult Dose for Pain: For mild to moderate severe chronic pain not requiring rapid onset of analgesic effect: Initial dose: 25 mg every morning Titration: increase in 25 mg increments as separate doses every 3 days to reach 100 mg per day taken as 25 mg 4 times per day. Then the total daily dose may be increased by 50 mg as tolerated every 3 days to reach 200 mg per day taken as 50 mg 4 times per day. Maintenance: After titration, tramadol 50 mg to 100 mg can be administered as needed for pain relief every 4 to 6 hours not to exceed 400 mg per day. For the management of moderate to moderately severe chronic pain in adults who require around-the-clock treatment of their pain for an extended period of time: Extended-Release Tablets: Initial Dose: 100 mg once daily and titrated up as necessary by 100 mg increments every five days to relief of pain and depending upon tolerability. Maximum Dose: Extended-release tablets should not be administered at a dose exceeding 300 mg per day. For patients in whom rapid onset of analgesic effect is required and for whom the benefits outweigh the risk of discontinuation due to adverse events associated with higher initial dose: Dose: 50 mg to 100 mg can be administered as needed for pain relief every 4 to 6 hours, not to exceed 400 mg per day. Tramadol Extended-Release (ER): Patients not currently treated with tramadol immediate-release (IR): Initial dose: 100 mg once daily and titrated up as necessary by 100 mg increments every 5 days to relief of pain and individualized according to patient need and tolerability. Maximum dose: 300 mg per day Patients currently on tramadol IR (immediare release) : Calculate the 24-hour tramadol IR dose: Initial dose: Round down to the next lowest 100 mg increment. The dose may subsequently be individualized according to patient need and tolerability. Maximum dose: 300 mg per day Due to limitations in flexibility of dose selection with tramadol ER, some patients maintained on immediate release products may not be able to convert. Usual Geriatric Dose for Pain: For patients over 65 years: Dose selection should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy. For patients over 75 years: Maximum dose of regular oral tablets: 300 mg per day in divided doses Usual Pediatric Dose for Pain: 4 to 16 years: Immediate release formulations: 1 to 2 mg/kg/dose every 4 to 6 hours Maximum single dose: 100 mg Maximum total daily dose is the lesser of: 8 mg/kg/day or 400 mg/day 16 years and older: Initial dose: 50 to 100 mg every 4 to 6 hours Maximum dose: 400 mg/day Alternatively, for patients not requiring a rapid onset of effect, side effects may be decreased by initiating dosage at 25 mg/day and increasing by 25 mg every 3 days up to 25 mg 4 times a day. Dosage may then be increased by 50 mg every 3 days as tolerated to 50 mg 4 times a day. 16 years and older: Oral disintegrating tablet (ODT): Initial: 50 to 100 mg every 4 to 6 hours Maximum: 400 mg/day Alternatively, for patients not requiring a rapid onset of effect, side effects may be decreased by initiating dosage at 50 mg/day and increasing by 50 mg every 3 days up to 50 mg 4 times a day. Maximum: 400 mg/day 16 years and older: Extended-release formulations: Initial: 100 mg once daily Titrate by 100 mg increments every 2 to 3 days if needed for pain control Maximum: 300 mg/day What other drugs will affect tramadol? Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking tramadol with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Many drugs can interact with tramadol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

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